Saint Mary's University of Minnesota had a total enrollment of 4,505 students in 2024. The full-time enrollment at Saint Mary's University of Minnesota is 2,558 students and the part-time enrollment is 1,947. This means that 56.8% of students enrolled at Saint Mary's University of Minnesota are enrolled full-time.

The enrolled student population at Saint Mary's University of Minnesota, both undergraduate and graduate, is 56.6% White, 8.24% Black or African American, 5.39% Hispanic or Latino, 3.84% Asian, 0.644% American Indian or Alaska Native, 0.488% Two or More Races, and 0.133% Native Hawaiian or Other Pacific Islanders.

Students enrolled at Saint Mary's University of Minnesota in full-time Undergraduate programs are most commonly White Female (32.3%), followed by White Male (29%) and Hispanic or Latino Female (5.55%). Students enrolled in full-time Graduate programs are most commonly White Female (36%), followed by White Male (11.4%) and Black or African American Female (6.11%).