University of Missouri-St Louis had a total enrollment of 14,736 students in 2024. The full-time enrollment at University of Missouri-St Louis is 5,027 students and the part-time enrollment is 9,709. This means that 34.1% of students enrolled at University of Missouri-St Louis are enrolled full-time.

The enrolled student population at University of Missouri-St Louis, both undergraduate and graduate, is 66.3% White, 13.9% Black or African American, 5.04% Asian, 4.36% Hispanic or Latino, 1.91% Two or More Races, 0.394% American Indian or Alaska Native, and 0.0271% Native Hawaiian or Other Pacific Islanders.

Students enrolled at University of Missouri-St Louis in full-time Undergraduate programs are most commonly White Female (31.8%), followed by White Male (28%) and Black or African American Female (11.4%). Students enrolled in full-time Graduate programs are most commonly White Female (29.7%), followed by White Male (17.5%) and Black or African American Female (8.8%).