Ponce Health Sciences University-Centro Universitario de San Juan had a total enrollment of 240 students in 2024. The full-time enrollment at Ponce Health Sciences University-Centro Universitario de San Juan is 234 students and the part-time enrollment is 6. This means that 97.5% of students enrolled at Ponce Health Sciences University-Centro Universitario de San Juan are enrolled full-time.

The enrolled student population at Ponce Health Sciences University-Centro Universitario de San Juan, both undergraduate and graduate, is 99.2% Hispanic or Latino, 0.417% White, and 0.417% Black or African American.

Students enrolled in full-time Graduate programs are most commonly Hispanic or Latino Female (87%), followed by Hispanic or Latino Male (12.6%) and Black or African American Female (0.216%).