Polytechnic University of Puerto Rico-Orlando had a total enrollment of 127 students in 2024. The full-time enrollment at Polytechnic University of Puerto Rico-Orlando is 41 students and the part-time enrollment is 86. This means that 32.3% of students enrolled at Polytechnic University of Puerto Rico-Orlando are enrolled full-time.

The enrolled student population at Polytechnic University of Puerto Rico-Orlando, both undergraduate and graduate, is 84.3% Hispanic or Latino, 3.15% Black or African American, and 1.57% White.

Students enrolled at Polytechnic University of Puerto Rico-Orlando in full-time Undergraduate programs are most commonly Hispanic or Latino Male (70.2%), followed by Hispanic or Latino Female (19.1%) and Black or African American Male (6.38%). Students enrolled in full-time Graduate programs are most commonly Hispanic or Latino Male (38.9%), followed by Hispanic or Latino Female (5.56%) and White Female (2.78%).