Columbia Southern University had a total enrollment of 17,763 students in 2024. The full-time enrollment at Columbia Southern University is 13,550 students and the part-time enrollment is 4,213. This means that 76.3% of students enrolled at Columbia Southern University are enrolled full-time.

The enrolled student population at Columbia Southern University, both undergraduate and graduate, is 57.3% White, 21% Black or African American, 2.89% Two or More Races, 1.95% Asian, 1.43% Hispanic or Latino, 0.929% American Indian or Alaska Native, and 0.67% Native Hawaiian or Other Pacific Islanders.

Students enrolled at Columbia Southern University in full-time Undergraduate programs are most commonly White Male (40.2%), followed by White Female (20.7%) and Black or African American Female (10.4%). Students enrolled in full-time Graduate programs are most commonly White Male (32.1%), followed by White Female (16.5%) and Black or African American Female (13.7%).