Oglala Lakota College had a total enrollment of 1,188 students in 2024. The full-time enrollment at Oglala Lakota College is 436 students and the part-time enrollment is 752. This means that 36.7% of students enrolled at Oglala Lakota College are enrolled full-time.

The enrolled student population at Oglala Lakota College, both undergraduate and graduate, is 96% American Indian or Alaska Native, 2.1% White, 0.758% Asian, 0.758% Two or More Races, 0.253% Hispanic or Latino, and 0.168% Black or African American.

Students enrolled at Oglala Lakota College in full-time Undergraduate programs are most commonly American Indian or Alaska Native Female (66.6%), followed by American Indian or Alaska Native Male (30.7%) and White Female (1.17%). Students enrolled in full-time Graduate programs are most commonly American Indian or Alaska Native Female (50%), followed by American Indian or Alaska Native Male (40%) and White Female (10%).