Le Moyne College had a total enrollment of 3,091 students in 2024. The full-time enrollment at Le Moyne College is 2,450 students and the part-time enrollment is 641. This means that 79.3% of students enrolled at Le Moyne College are enrolled full-time.

The enrolled student population at Le Moyne College, both undergraduate and graduate, is 72.2% White, 8.12% Hispanic or Latino, 7.93% Black or African American, 4.69% Asian, 2.94% Two or More Races, 0.226% American Indian or Alaska Native, and 0.0647% Native Hawaiian or Other Pacific Islanders.

Students enrolled at Le Moyne College in full-time Undergraduate programs are most commonly White Female (42.3%), followed by White Male (30%) and Hispanic or Latino Female (5%). Students enrolled in full-time Graduate programs are most commonly White Female (53.7%), followed by White Male (17.8%) and Asian Female (6.67%).