Missouri State University-Springfield had a total enrollment of 24,360 students in 2024. The full-time enrollment at Missouri State University-Springfield is 13,387 students and the part-time enrollment is 10,973. This means that 55% of students enrolled at Missouri State University-Springfield are enrolled full-time.

The enrolled student population at Missouri State University-Springfield, both undergraduate and graduate, is 76.2% White, 5.6% Hispanic or Latino, 4.45% Two or More Races, 3.46% Black or African American, 2.21% Asian, 0.382% American Indian or Alaska Native, and 0.0862% Native Hawaiian or Other Pacific Islanders.

Students enrolled at Missouri State University-Springfield in full-time Undergraduate programs are most commonly White Female (50%), followed by White Male (29.7%) and Hispanic or Latino Female (3.4%). Students enrolled in full-time Graduate programs are most commonly White Female (42.1%), followed by White Male (18.4%) and Hispanic or Latino Female (2.21%).