Hannibal-LaGrange University had a total enrollment of 499 students in 2024. The full-time enrollment at Hannibal-LaGrange University is 386 students and the part-time enrollment is 113. This means that 77.4% of students enrolled at Hannibal-LaGrange University are enrolled full-time.

The enrolled student population at Hannibal-LaGrange University, both undergraduate and graduate, is 70.1% White, 7.21% Black or African American, 4.81% Hispanic or Latino, 4.21% Two or More Races, 0.802% Asian, 0.601% American Indian or Alaska Native, and 0.2% Native Hawaiian or Other Pacific Islanders.

Students enrolled at Hannibal-LaGrange University in full-time Undergraduate programs are most commonly White Female (40.2%), followed by White Male (28%) and Black or African American Male (5.8%). Students enrolled in full-time Graduate programs are most commonly White Female (57.6%), followed by White Male (24.2%) and Hispanic or Latino Female (6.06%).