Wilkes University had a total enrollment of 5,381 students in 2024. The full-time enrollment at Wilkes University is 2,374 students and the part-time enrollment is 3,007. This means that 44.1% of students enrolled at Wilkes University are enrolled full-time.

The enrolled student population at Wilkes University, both undergraduate and graduate, is 65.9% White, 12.4% Black or African American, 8.88% Hispanic or Latino, 4.76% Asian, 2.88% Two or More Races, 0.13% American Indian or Alaska Native, and 0.112% Native Hawaiian or Other Pacific Islanders.

Students enrolled at Wilkes University in full-time Undergraduate programs are most commonly White Female (34.8%), followed by White Male (33.2%) and Hispanic or Latino Female (5.99%). Students enrolled in full-time Graduate programs are most commonly White Female (52.1%), followed by White Male (24%) and Black or African American Female (6.46%).