Vanguard University of Southern California had a total enrollment of 2,246 students in 2024. The full-time enrollment at Vanguard University of Southern California is 1,869 students and the part-time enrollment is 377. This means that 83.2% of students enrolled at Vanguard University of Southern California are enrolled full-time.

The enrolled student population at Vanguard University of Southern California, both undergraduate and graduate, is 44.7% Hispanic or Latino, 31% White, 5.39% Black or African American, 5.3% Asian, 3.07% Two or More Races, 0.445% Native Hawaiian or Other Pacific Islanders, and 0.312% American Indian or Alaska Native.

Students enrolled at Vanguard University of Southern California in full-time Undergraduate programs are most commonly Hispanic or Latino Female (34.2%), followed by White Female (19.9%) and Hispanic or Latino Male (14.6%). Students enrolled in full-time Graduate programs are most commonly White Female (29.1%), followed by Hispanic or Latino Female (22.5%) and White Male (11.5%).