University of Virginia's College at Wise had a total enrollment of 2,167 students in 2024. The full-time enrollment at University of Virginia's College at Wise is 1,224 students and the part-time enrollment is 943. This means that 56.5% of students enrolled at University of Virginia's College at Wise are enrolled full-time.

The enrolled student population at University of Virginia's College at Wise, both undergraduate and graduate, is 42.9% White, 9.69% Black or African American, 2.22% Hispanic or Latino, 1.52% Asian, 1.29% Two or More Races, and 0.138% American Indian or Alaska Native.

Students enrolled at University of Virginia's College at Wise in full-time Undergraduate programs are most commonly White Female (22%), followed by White Male (17.3%) and Black or African American Male (3.42%). Students enrolled in full-time Graduate programs are most commonly White Male (40%), followed by White Female (40%) and Two or More Races Female (6.67%).