University of Southern Maine had a total enrollment of 7,604 students in 2024. The full-time enrollment at University of Southern Maine is 4,115 students and the part-time enrollment is 3,489. This means that 54.1% of students enrolled at University of Southern Maine are enrolled full-time.

The enrolled student population at University of Southern Maine, both undergraduate and graduate, is 77.1% White, 6.63% Black or African American, 4.02% Two or More Races, 3.98% Hispanic or Latino, 2.59% Asian, 0.71% American Indian or Alaska Native, and 0.0395% Native Hawaiian or Other Pacific Islanders.

Students enrolled at University of Southern Maine in full-time Undergraduate programs are most commonly White Female (45.6%), followed by White Male (29.9%) and Black or African American Female (4.57%). Students enrolled in full-time Graduate programs are most commonly White Female (59.3%), followed by White Male (20.5%) and Two or More Races Female (2.69%).