St. Mary's University had a total enrollment of 3,456 students in 2024. The full-time enrollment at St. Mary's University is 2,901 students and the part-time enrollment is 555. This means that 83.9% of students enrolled at St. Mary's University are enrolled full-time.

The enrolled student population at St. Mary's University, both undergraduate and graduate, is 44.7% Hispanic or Latino, 22.3% White, 2.78% Black or African American, 1.85% Asian, 0.897% Two or More Races, 0.694% American Indian or Alaska Native, and 0.289% Native Hawaiian or Other Pacific Islanders.

Students enrolled at St. Mary's University in full-time Undergraduate programs are most commonly Hispanic or Latino Female (34%), followed by Hispanic or Latino Male (19.9%) and White Female (5.69%). Students enrolled in full-time Graduate programs are most commonly Hispanic or Latino Female (24.3%), followed by White Female (17.6%) and Hispanic or Latino Male (16.6%).