Southwestern Oklahoma State University had a total enrollment of 5,186 students in 2024. The full-time enrollment at Southwestern Oklahoma State University is 3,464 students and the part-time enrollment is 1,722. This means that 66.8% of students enrolled at Southwestern Oklahoma State University are enrolled full-time.

The enrolled student population at Southwestern Oklahoma State University, both undergraduate and graduate, is 61.3% White, 12.4% Hispanic or Latino, 10.6% Two or More Races, 4.36% Black or African American, 3.64% American Indian or Alaska Native, 1.93% Asian, and 0.0964% Native Hawaiian or Other Pacific Islanders.

Students enrolled at Southwestern Oklahoma State University in full-time Undergraduate programs are most commonly White Female (37.5%), followed by White Male (23.8%) and Hispanic or Latino Female (9.55%). Students enrolled in full-time Graduate programs are most commonly White Female (44.3%), followed by White Male (16.9%) and Two or More Races Female (7.76%).