High Desert Medical College had a total enrollment of 2,280 students in 2024. The full-time enrollment at High Desert Medical College is 2,189 students and the part-time enrollment is 91. This means that 96% of students enrolled at High Desert Medical College are enrolled full-time.

The enrolled student population at High Desert Medical College, both undergraduate and graduate, is 61.9% Hispanic or Latino, 13.8% White, 12.8% Black or African American, 4.21% Asian, 3.33% Two or More Races, 0.658% American Indian or Alaska Native, and 0.57% Native Hawaiian or Other Pacific Islanders.

Students enrolled at High Desert Medical College in full-time Undergraduate programs are most commonly Hispanic or Latino Female (55.4%), followed by White Female (12.9%) and Black or African American Female (11.5%).