Otterbein University had a total enrollment of 2,332 students in 2024. The full-time enrollment at Otterbein University is 2,122 students and the part-time enrollment is 210. This means that 91% of students enrolled at Otterbein University are enrolled full-time.

The enrolled student population at Otterbein University, both undergraduate and graduate, is 69.2% White, 12.5% Black or African American, 5.45% Two or More Races, 5.02% Hispanic or Latino, 3.56% Asian, 0.515% Native Hawaiian or Other Pacific Islanders, and 0.0858% American Indian or Alaska Native.

Students enrolled at Otterbein University in full-time Undergraduate programs are most commonly White Female (42.2%), followed by White Male (27%) and Black or African American Female (6.74%). Students enrolled in full-time Graduate programs are most commonly White Female (48.8%), followed by White Male (32.5%) and Black or African American Female (5.69%).