Southeast Missouri State University had a total enrollment of 9,501 students in 2024. The full-time enrollment at Southeast Missouri State University is 6,711 students and the part-time enrollment is 2,790. This means that 70.6% of students enrolled at Southeast Missouri State University are enrolled full-time.

The enrolled student population at Southeast Missouri State University, both undergraduate and graduate, is 67.8% White, 6.7% Black or African American, 3.01% Two or More Races, 2.87% Hispanic or Latino, 0.926% Asian, 0.263% American Indian or Alaska Native, and 0.0421% Native Hawaiian or Other Pacific Islanders.

Students enrolled at Southeast Missouri State University in full-time Undergraduate programs are most commonly White Female (43.6%), followed by White Male (28.1%) and Black or African American Female (4.77%). Students enrolled in full-time Graduate programs are most commonly White Female (17.8%), followed by White Male (7.5%) and Black or African American Female (1.98%).