California Polytechnic State University-San Luis Obispo had a total enrollment of 23,069 students in 2024. The full-time enrollment at California Polytechnic State University-San Luis Obispo is 22,005 students and the part-time enrollment is 1,064. This means that 95.4% of students enrolled at California Polytechnic State University-San Luis Obispo are enrolled full-time.

The enrolled student population at California Polytechnic State University-San Luis Obispo, both undergraduate and graduate, is 47.8% White, 25% Hispanic or Latino, 13.8% Asian, 8.02% Two or More Races, 0.75% Black or African American, 0.217% Native Hawaiian or Other Pacific Islanders, and 0.121% American Indian or Alaska Native.

Students enrolled at California Polytechnic State University-San Luis Obispo in full-time Undergraduate programs are most commonly White Female (25.1%), followed by White Male (23.4%) and Hispanic or Latino Female (12.3%). Students enrolled in full-time Graduate programs are most commonly White Female (27.2%), followed by White Male (26.8%) and Hispanic or Latino Male (10.2%).