Pennsylvania State University-Penn State Harrisburg had a total enrollment of 4,478 students in 2024. The full-time enrollment at Pennsylvania State University-Penn State Harrisburg is 3,989 students and the part-time enrollment is 489. This means that 89.1% of students enrolled at Pennsylvania State University-Penn State Harrisburg are enrolled full-time.

The enrolled student population at Pennsylvania State University-Penn State Harrisburg, both undergraduate and graduate, is 46.7% White, 13.5% Asian, 9.78% Black or African American, 9.18% Hispanic or Latino, 3.77% Two or More Races, and 0.0893% American Indian or Alaska Native.

Students enrolled at Pennsylvania State University-Penn State Harrisburg in full-time Undergraduate programs are most commonly White Male (27.9%), followed by White Female (17.5%) and Asian Male (7.76%). Students enrolled in full-time Graduate programs are most commonly White Female (16.8%), followed by White Male (10.2%) and Black or African American Female (4.03%).